Extraction of the Antimalarial Artemisinin from Artemisia Annua L. Leaves with Supercritical Co2
نویسندگان
چکیده
The antimalarial artemisinin, the active principle of the plant Artemisia annua L., was extracted by Supercritical Fluid Extraction (SFE). Soxhlet extraction was studied as comparison processes. The extracts were analyzed by the indirect method GC-FID. The maximal extraction yield (1.82%DW) was obtained by SFE at T=40°C, P=200bar, CO2flow=4.5g/min, and 20% ethanol as modifier. The artemisinin extraction can be enhanced by adding of non-polar modifier, this fact is applicable for the Soxhlet extraction also. Further was studied the kinetic of the extraction and fitting the experimental data with several mass transfer models.
منابع مشابه
In vitro susceptibility of Plasmodium falciparum Welch field isolates to infusions prepared from Artemisia annua L. cultivated in the Brazilian Amazon.
Artemisinin is the active antimalarial compound obtained from the leaves of Artemisia annua L. Artemisinin, and its semi-synthetic derivatives, are the main drugs used to treat multi-drug-resistant Plasmodium falciparum (one of the human malaria parasite species). The in vitro susceptibility of P. falciparum K1 and 3d7 strains and field isolates from the state of Amazonas, Brazil, to A. annua i...
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